V8 also doesn't run js, it does some byte code compilation stuff amongst other things, then interprets that. But that's all a bit pedantic too, V8 runs js, deno runs ts.
fwiw https://deno.com even has as one of their first bullet points that they have "native support for TypeScript and JSX"
What about pkcon? I haven't used it in particular, but packagekit based GUIs work pretty well in my experience, and then it supports flatpak/snap/apt/kde addons/etc in one interface, which is better than it was originally.