I (probably unreasonably) despise using web front-ends for desktop applications.
GTK is OK. QT is very feature rich, but that adds complexity. Both can be cross-compiled to most systems and shipped with all the required libraries pretty easily.
I haven't used it in a long while, but I remember liking Java Swing for some reason. Java should be "write once, run anywhere." But, cross-compiling isn't usually too hard, so not sure how much that matters. There's more modern frameworks for JVM-based languages now, but I haven't tried them.
I've noticed Gradio is popular in the ML community (web-tech based, and mostly used for quick demos/prototypes).
Edit: For web applications, I prefer Angular's more traditional architecture over React's hook architecture.