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Nowadays, you can test for anesthetic drug resistances with DNA site testing, (as in, a blood test), though of course, this does not mean that it is always used, for various reasons.
A personal anecdote:
I've had one done after I had bad side-effects to ADHD medication I had tried, and I haven't had any bad effects in the medications I've tried since. (besides drowsiness)
Edit: I want to say, I'm not saying that getting the dosage right is not incredibly difficult, I just wanted to mention that we can detect drug allergies without putting them under, (so to speak).
That’s good to know! I just swelled up for a week because my new dentist used a different kind of local anesthetic, so it was close to the front of my mind. That would have helped a lot