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Therapy and anti-depressants
Edit: tbh, I see how the question is framed as a general question too.
I think overall, therapy is a great solution. I wish it was easier to start the process in the states. Surprisingly I haven't had any experience truly understanding anti-depressants or being close to those that took them and were open talking about them. I wish I knew more about their effects on how they help with self-assurance.
Depends on the person or the medicine. So your results may vary. Basically anti-depressants for me lessen the impact of depression. So when the idea pops into your head that that is negative or self doubting it's easier to reflect and evaluate if that thought is correct or not. As well it helps with break negativity chains where something goes wrong and a bad mood continues for several events. That is a confidence killer.