This last part sounds nice in theory, but it's way outside the scope of what Typescript is intended to accomplish. I've been pursuing a similar goal on and off for 10+ years at this point, I even wrote an ORM for Backbone.js so I could use it on the server as well. Back then we called it Isomorphic Javascript, later on it got renamed to "universal javascript", nowadays I'm not sure.

But yeah, the problem is similar with any code, really... What you're often writing in software dev is just functions, but the infrastructure required to actually call said function is often not trivial. I agree it'd be nice to be able to have different "wrapper types" easily, but I'm afraid their usefulness would be limited beyond toy projects.