Estrogen therapy for transfems takes a while to have noticeable effects.
Two of the earliest effects for people are softer skin and growing areolas. I read a blog yesterday where the author said one of the first effects she noticed was her nipples growing to look like cis women's.
Just googled and T is said to make the nipples darker and shrink the areolas quite quickly, so yes!
I am assuming the comic/caption is transfem because folks tend to socially transition before starting hormones.