this post was submitted on 17 Jul 2023
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Don’t You Know Who I Am?

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submitted 1 year ago* (last edited 1 year ago) by [email protected] to c/[email protected]
 
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[–] [email protected] 22 points 1 year ago (2 children)

Not to nitpick but to me the title of this post is implying that XXY individuals are born female. Generally they’re born male.

What the comment is referring to is likely Swyer Syndrome, where the individual has an XY configuration but a dysfunctional gene in the sex-determining region of the Y chromosome. This means the embryo develops female anatomy and the resulting children tend to identify female, but they lack functional gonadal tissue. It’s estimated to occur at a rate of about 1 in a 100,000 females.

By the by, treatment for these individuals usually involves removing the dysfunctional gonadal tissue as it often becomes cancerous (which often gets misunderstood as “gender reassignment surgery”) and supplemental hormone replacement therapy. They would be affected too by any bans on hormone administration to kids often connected with trans people. One of the reasons why blanket bans should be a no-go regardless of how you feel about any other trans issue.

[–] [email protected] 4 points 1 year ago (1 children)

I think we can safely say that is nitpicking, but it’s informative and correct so I’m all for it!

From my biology lessons 20 years ago, I thought I was taught that it was the presence of a second X chromosome that made a person genetically female, but I could definitely be misremembering. Either way, XXY individuals are usually born male, and Dr Genetics Federation was likely talking about sawyer syndrome (or so google tells me). Thanks for the correction!

[–] [email protected] 2 points 1 year ago (1 children)

Not in humans, no! While in some animals sex determination is purely about X dosage (Drosophila), in humans the Y chromosome is actually sex-determining. In females the second X chromosome actually gets inactivated as a means of gene dosage compensation.

[–] [email protected] 1 points 1 year ago

TIL, thanks!

[–] [email protected] 3 points 1 year ago

Or, androgen insensitivity syndrome, specifically complete androgen insensitivity syndrome:

Androgen insensitivity syndrome (AIS) is a difference in sex development involving hormonal resistance due to androgen receptor dysfunction.

Complete androgen insensitivity syndrome (CAIS) is an AIS condition that results in the complete inability of the cell to respond to androgens.

The unresponsiveness of the cell to the presence of androgenic hormones prevents the masculinization of male genitalia in the developing fetus, as well as the development of male secondary sexual characteristics at puberty, but does allow female genital and sexual development in those with the condition.

Individuals affected by CAIS develop a normal external female habitus, despite the presence of a Y chromosome, but internally, they will lack a uterus, and the vaginal cavity will be shallow, while the gonads, having been turned into testicles rather than ovaries in the earlier separate process also triggered by their Y chromosome, will remain undescended in the place where the ovaries would have been.

Most individuals with CAIS are raised as females.They are born phenotypically female and are usually heterosexual with a female gender identity; however, at least two case studies have reported male gender identity in individuals with CAIS.

[–] [email protected] 11 points 1 year ago (2 children)

I decided to Google it just to be safe

And yes he is lmao

[–] [email protected] 5 points 1 year ago (1 children)

And 5 time finalist of the Eureka Prize - which sounds impressive even if I’ve never heard of it!

[–] [email protected] 1 points 1 year ago (1 children)

Just saying the word eureka is exciting

[–] [email protected] 0 points 1 year ago (1 children)

Not if you live in north west California, then it's just a town name.

[–] [email protected] 0 points 1 year ago (1 children)

Isn't it latin for 'fetch me my towel'?

[–] [email protected] 1 points 1 year ago

According to Wikipedia

"Eureka" comes from the Ancient Greek word εὕρηκα heúrēka, meaning "I have found (it)", which is the first person singular perfect indicative active of the verb εὑρίσκω heurískō "I find". It is closely related to heuristic, which refers to experience-based techniques for problem-solving, learning, and discovery.

[–] [email protected] 0 points 1 year ago

Just a few letters shy of the acronym PIGFUCKER

[–] [email protected] 3 points 1 year ago

Sometimes people just want to believe what they believe or ignorance is bliss...

[–] [email protected] 1 points 1 year ago (1 children)

Mic drop...

I am curious about the video though

[–] [email protected] 2 points 1 year ago* (last edited 1 year ago)

Transphobic BS I believe. But I’m not trawling through fb to find the original.

[–] [email protected] 1 points 1 year ago

I was having a civil and boring discussion with someone on a (non-anonymous) forum once about a highly specific technical thing, and then some random person decides to write something along the lines of "I have nothing to add to this conversation, but I just want to point out that the guy you're talking to is actually an employee of :)"

I don't know if that guy felt any cringe after posting that, but I sure as hell felt it for him. Neither of us really knew how to respond to that, and it kind of just killed the discussion to avoid that awkwardness.

Sometimes I still think about that guy. Is he still vicariously Pretty Woman'ing people? Did he accomplish some of his life goals? I hope so.

[–] [email protected] 0 points 1 year ago (1 children)

Being a president of something doesn't mean crap though.

[–] [email protected] 0 points 1 year ago* (last edited 1 year ago) (1 children)

It does if it's as prestigious and well known as the International Genetics Federation.

[–] [email protected] 0 points 1 year ago (1 children)

It doesn't. Administrative work requires different set of skills of knowledge from scientist work.

[–] [email protected] 1 points 1 year ago* (last edited 1 year ago)

Well, he has a doctorate and has been cited over 13,000 times. So for this particular institution, it absolutely does.

[–] [email protected] -1 points 1 year ago* (last edited 1 year ago) (3 children)

Is he mixing up people with 3 gonosomes?

Because these are not too rare. It’s one of the more frequent mutations.

But even a person with XXY is a male. Since the male gonosome is considered as a mutation of an X chromosome. Somewhere in the evolution of mammals and other vertebrates (or most likely much earlier) something messed up and created the Y chromosome from an X chromosome. That’s why genetic diseases are usually more frequent in males, since one branch of the X chromosome does not have some backup. It’s simply missing.

So whenever a person has one Y chromosome. It is considered male. The lack of a Y chromosome is considered a female.

This can also be seen in people with genetic disorders, such as three gonosomes. XXX is a female XYY is a male XXY is also a male.

And to everyone’s information: I am for Germany and we do not have two words for sex and gender.

I don’t understand what you English speakers are up to.

[–] [email protected] 2 points 1 year ago

You had me up to:

And to everyone’s information: I am for Germany and we do not have two words for sex and gender. I don’t understand what you English speakers are up to.

I don’t understand what you mean here? I’m sure biological sex and gender identity are considered separate ideas even in languages without a specific word for them. To my mind a lot of transphobia comes from people not understanding there’s a difference between sex and gender.

As for the XXY, I’m OP and that’s my mistake. I misremembered my biology lessons and thought a second X chromosome made someone biological female, rather than the presence of an Y chromosome making someone male. I replied to someone else explaining my mistake.

[–] [email protected] 2 points 1 year ago (1 children)

I just wrote a comment above but I believe OP is mixing XXY with what the comment was about, which is likely Swyer Syndrome: XY individuals with female anatomy and gonadal dysgenesis. While they have a Y chromosome, a defective sex-determining gene leads to a failure to sexually differentiate into male gonadal tissue and leads to subsequent loss of downstream sex hormone production.

[–] [email protected] 0 points 1 year ago* (last edited 1 year ago) (2 children)

So I assume such people are identified as females at birth. But if their chromosomes indicate that they are male, what’s the gender then?

I think it’s a male then, right? Because when a defect leads to malformations, it still is a malformation. One that people could probably live very well with.

[–] [email protected] 2 points 1 year ago* (last edited 1 year ago)

If male and female are assigned purely based on physical anatomy, does it really matter?

No one in that person's life would consider them male and doctors would treat them based on their sex characteristics - they may have testes but they wouldn't be external.

I have never been karyotyped and I'm willing to bet most people haven't either; your sex is assumed based on your outward appearance even when your genitals are not observable.

I really don't think that having a Y chromosome makes you male when you literally have a vagina, you know? Especially when you could go your whole life without knowing.

[–] [email protected] 2 points 1 year ago

If the SRY gene is broken, they'd still physically develop as female, though potentially with some abnormalities, rather than as male. Even leaving gender identity out of it, sex is still more complicated than if exists Y; then male

[–] [email protected] 2 points 1 year ago (1 children)

As an English speaker, trust me you don’t wanna know. Don’t dive into it

[–] [email protected] 0 points 1 year ago (1 children)

Well, since there is just one word in German for sex and gender, it’s the same thing here, some people try to use the English word gender (untranslated) here.

But I simply don’t understand why this is needed. It’s getting so mixed up and complicated, but at the same time it barely has any relevance. Because what does it add to society, dialogue or communication? German is a very precise language, and I don’t understand why some people try to soften it up with the English term of gender. It’s so weird.

[–] [email protected] 0 points 1 year ago (1 children)

I’m pretty sure alot of people use it interchangeably to mean the same thing. But I think over the years, gender has become more of a “social” word and Sex as more of a “biological” word. I say Gender instead of sex when talking about someone’s biology. A bit confusing honestly for non-native English speakers

[–] [email protected] 1 points 1 year ago

This:

I think over the years, gender has become more of a “social” word and Sex as more of a “biological” word.

Seems at odds with:

I say Gender instead of sex when talking about someone’s biology.

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