A lot of the more popular ones have been listed already but here's a couple that I loved that are a bit more off the beaten path:
Tv:
- Little Bird - drama, if you want to cry your eyes out and watch a fantastic story about the consequences of the 60s scoop
- Late Bloomer - comedy by YouTuber Jasmeet Dutta
Music (indigenous):
- snotty nose Rez kids - rap/hiphop
- anachnid - electronic, I guess?
Nonindigenous:
- kimmortal - alt hiphop
- shad - alt hiphop
- mother mother - indie rock
- said the whale - indie rock
- the Jerry cans - folk (Inuktitut language and style)
Podcast:
- Stolen - true crime
Adding video games too:
- Don't starve (and any Klei game actually)
- crypt of the necrodancer
- starbound (s/o even though I think they're UK based not Canadian)