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Big brain tech dude got yet another clueless take over at HackerNews etc? Here's the place to vent. Orange site, VC foolishness, all welcome.

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Stubsack: weekly thread for sneers not worth an entire post, week ending Sunday 12 May 2024 (awful.systems)

submitted 6 months ago by [email protected] to c/[email protected]

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Have a sneer percolating in your system but not enough time/energy to make a whole post about it? Go forth and be mid!

Any awful.systems sub may be subsneered in this subthread, techtakes or no.

If your sneer seems higher quality than you thought, feel free to cut’n’paste it into its own post, there’s no quota for posting and the bar really isn’t that high

The post Xitter web has spawned soo many “esoteric” right wing freaks, but there’s no appropriate sneer-space for them. I’m talking redscare-ish, reality challenged “culture critics” who write about everything but understand nothing. I’m talking about reply-guys who make the same 6 tweets about the same 3 subjects. They’re inescapable at this point, yet I don’t see them mocked (as much as they should be)
Like, there was one dude a while back who insisted that women couldn’t be surgeons because they didn’t believe in the moon or in stars? I think each and every one of these guys is uniquely fucked up and if I can’t escape them, I would love to sneer at them.

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[–] [email protected] 3 points 6 months ago (1 children)

also note that the big failures come from faulty biology, not from faulty chemistry. You can set innumerable piles of cash on fire if you choose to plug a wrong enzyme

[–] [email protected] 4 points 6 months ago* (last edited 6 months ago)

elaborating on that. when you can hit a protein cleanly (without some side effects (called off-target, there are also on-target side effects)) but you hit wrong protein, this doesn't have to be a complete loss, but it's likely. maybe you learn something, either about biology of that all or about something else that it interacts with, or maybe you have found a cure to some other disease instead. but this is the actual hard problem of drug development, especially when the biology of it all is little known. there's a few of these drugs that started this way, fentanyl, viagra, thalidomide (as anticancer), minoxidil come to mind, and at worst you have a new tool for biologists. alphafold won't help with that