this post was submitted on 07 Nov 2023
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[–] [email protected] 21 points 1 year ago (3 children)

My friend works out and takes pain meds frequently.

He also complains about yearly kidney stones.

I have never had a kidney stone. Where he's on his 8th one.

[–] [email protected] 16 points 1 year ago

Yeah, they're partly genetic but you can risk it. I have a couple of friends who have had their third or fourth stone and I've never felt so much as a slight discomfort on my kidneys. It makes me wonder wtf they're doing to themselves but I'm not one to judge.

[–] [email protected] 11 points 1 year ago* (last edited 1 year ago)

Was he on narcotics? I'm finding no link between Acetaminophen or Ibuprofen to kidney stones. Just drink more water.

https://www.utsouthwestern.edu/newsroom/articles/year-2023/june-prevent-kidney-stones.html

https://pubmed.ncbi.nlm.nih.gov/30829133/

Ibuprofen is mostly processed by your liver as well. Acetaminophen uses a bit of both.

This appears to occur predominantly systemically in the liver [1,10], but may occur pre-systemically in the gut as well [11]. Ibuprofen is almost completely metabolized, with little to no unchanged drug found in the urine [1,9,12].

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4355401/

Acetaminophen (APAP) is normally metabolized in the liver and kidney by P450 enzymes. No toxicity is observed with therapeutic doses of APAP.

https://www.goodrx.com/acetaminophen/is-tylenol-acetaminophen-bad-for-your-liver-or-kidneys

https://pubmed.ncbi.nlm.nih.gov/8669426/

Tylenol (acetaminophen) is almost completely broken down by the liver. During this process, a toxic chemical forms. Normally, the liver makes it non-toxic. But if you take too much Tylenol, the liver can't properly process it all. The toxic chemical can then build up and poison liver cells.

https://www.goodrx.com/acetaminophen/is-tylenol-acetaminophen-bad-for-your-liver-or-kidneys

[–] [email protected] 3 points 1 year ago

That was definitely the cause of my kidney stone, because I don't take OTC pain meds frequently, but if you do have ways to avoid kidney stones, avoid kidney stones. They are no fun.