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well in pain meditation/placebo is kinda borderline pseudo science, it's a mind over matter thing eh, it may effect or not, but if we take the route of protein interaction, madaling makita yung direct science sa effect nung substance sa dopamine, serotonin, endorphins, oxytocin and the likes.
sa recreational, it's tricky since it's prone to abuse, we don't know how to properly regulate it, so we are not ready for that, but when and if that time comes na okay na, I want to try it for once, para naman makaescape sa reality.
I don't know about the protein interaction you're talking about, but if you're talking about hormones able to bind to any cell in your body and have its effects, then I already knew that, learnt it from Huberman, meditation increases serotonin level which is the body's natural pain killer so it's not unscientific.
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2931548/
To be honest, I admit I can't understand it, now if you understood it explain in layman's terms, now if you expound this again,
you're trying to confuse me since dopamine lang ang nandoon sa source mo sa link, and dopamine is a pleasure hormone so it could be more about pleasure and less or not about pain