Clever_Clover

Gonna start calling myself a thinktank and writing transhumanist sci-fi seeseepee fan fiction

so what i don't understand is how prions can be resisted

basically all prion diseases that we know of are not curable and have a 100% fatality rate

and whether the epidemiology of a prion disease is about who ingests/receives an incorrectly folded protein

well, it can depend on some things, like for example if there was a difference in how well your body worked without that certain protein being functional compared to another person who is less resilient when this particular protein doesn't work well, it's kind of the reason why the incubation period varies so widely, the build up and conversion from good proteins to misfolded ones isn't instant and takes time, so until that build up gets to a level where it causes symptoms we just don't know that the person has anything wrong with them

or about individuals with particularly... foldable? proteins getting a prion and developing an illness that others wouldn't.

there's variation between people of course, but no if a prion is a certain protein and you expose it to proteins of the same kind it makes them misfold, maybe certain people have a different variation of that protein that does the same job but is structured a little differently so it's not as susceptible or at all even, but that's speculation on my part, I haven't read deeply into this particular topic, generally speaking research into prion disease is still very inadequate, it's very rare, and is always fatal, so it's kind of hard to do research on

i'm particularly confused because the immune system isn't involved, is it?

yeah the immune system can't really fight it typically, because the protein matches the ones that the body uses, there isn't much to tip it off since the immune system doesn't look at protein folding, it looks at what proteins, sugars, and other molecules something has, in fact, the immune system can actually help the prion disease move into the body and reduce the incubation period as was seen in this study on rats, https://sci-hub.se/https://doi.org/10.1006/clim.2000.4875

oh also, not every exposure would mean 100% getting infected, especially since the propagation of the misfolding isn't instant and takes time, so if those proteins get disposed of and replaced before they can spread (as the body naturally does dismantle and rebuild lots of proteins) then you wouldn't get infected

though keep in mind that these are rare diseases, that affect like 1-2 people per million worldwide every year, some of those cases are due to infection (acquired), some are due to genetic issues that are inherited, meaning the body itself makes misfolded proteins sometimes due to genes being coded with a bad mutation in the area that codes for that protein, and some are just sporadic, meaning one protein just decides to misfold because it got built slightly wrong cause that person is extremely unlucky and then it spreads

more reading here https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4890484/

generally speaking, not something you wanna ever risk the chance of making more common

first of all, the game is alright, and second there isn't actually any sex, it's just a horror game with an extremely abusive manipulative sister/brother dynamic where there are a lot of fucked up things that happen like eating the neighbor, sacrificing souls to a demon, etc, near the end of the game there's a choice you can make that is that the sister gets more serious about making sure her brother is only hers and that implies incest, for some reason people on twitter got really mad at the inclusion of incest as a topic when it's very obviously not an endorsement but a bad theme like all of the others the game gets into

testing for prions, especially for ones that you don't know of yet (which can develop at any time in any person due to the nature of prions, but that's very very rare) is extremely difficult, when mad cow disease is detected in a cattle herd you cull the herd, it isn't worth it, the risk is far too high, and prions cannot be removed through anti-biotics or any kind of treatment, the only way to destroy them is denaturation through burning

prions are misshapen proteins that 'spread' in that when they touch the normally shaped proteins of the same kind they can cause them to become misshapen in the same way too, and being misshapen means this protein can't do its job, and when it's job is keeping your brain working or doing other important biological functions, you can see where issues arise

someone who was healthy at the end of their life may have prions in their body that were dormant and did not show symptoms, the longer you live the more likely you are to have proteins become misshapen, most are harmless and wouldn't spread anyway, and most people die without developing anything to do with prions because of just how unlikely it is to happen

but in the rare chance someone's body produces a misfolded protein that is both infectious and affects an important biological function then that extremely small chance would be buried in the ground or incinerated the majority of the time, but if more people practiced cannibalism then that protein would have a field day as it spread to the first person and then through blood contact spread to others, because a lot of prion disease is slow acting and/or has a very long incubation period (multiple years)

so not practicing cannibalism makes it a lot less likely for an untreatable deadly prion disease to materialize

on discord on linux you can't screenshare with desktop audio, I think this might be already fixed in newer electron versions (but discord is closed source and has not updated their electron in a long time)

Those people miss the point

People don't eat out of some logical conclusion they reached that they need to eat a certain amount of calories

People eat because they're hungry, people eat too much because the food that is available to them and that is advertised to them isn't as filling (and a lot of the time due to bad habits that form, emotional eating, etc)

Someone being obese is not an issue of them knowing or not knowing that eating a surplus of calories is what increases weight, so this fact is irrelevant, everyone knows eating more makes you gain weight.

So, a drug that makes you eat less is something that magically helps you lose weights, because it solves something lower on the chain (being hungry), going even lower to the source would be eating better food, fixing bad habits and becoming healthier in other ways, but those are difficult non-magical solutions, taking a pill or an injection is much more of a magical solution.

Something something I hope for a future where I'll face the wall for being a reactionary something something

For people frequently chanting about death to various things, y'all are surprisingly literal.

He thinks the death to america posts aren't literal

I of course know and absolutely condemn that, again what is your point?

You do not know what these words mean and you do not truly condemn them, that's clear by the arguments you make

Israel is the most diverse country in the whole region without question

"Without question" since when are you a middle east expert? How many years did it take to get your doctorate degree on the subject?

Israel is not diverse, an apartheid state cannot be applauded for having the second class citizens be of a different race, by your logic south Africa during apartheid was the most diverse country in the southern African region

and it is also also the only democracy

Do you know what an apartheid state is? Could you give me that definition, and then give me the definition of a democracy, and try to weasel your way out of the contradiction that an apartheid state can't be a democracy

Other countries in the region are monarchies or (often military) dictatorships.

The UK is a monarchy, but I bet you think it's democratic to some degree, are you aware that a lot of the monarchies in the region employ a similar parliamentary system?

Israel is also the only country in the region that has womens and LGBTQ+ rights written into it's law

You can blame CIA funding the religious extremist reactionaries (and also the british bringing in the criminalization of lgbtq people during their colonial rule over the region) for the oppressive laws that exist in the region, but despite that it's not as bad in certain countries that are more progressive, a lot of the middle eastern countries are on the level of Serbia/other reactionary Balkan countries in terms of lgbtq stuff

Israel is not really better for lgbtq people, especially Palestinian citizens of Israel that belong to that group, they are very heavily oppressed and regularly harassed and even get blackmailed by the IDF due to their identities

You show that you don't know anything about the region, just repeat the propaganda and pink washing that you've been fed.

while in all other countries in the region women are being oppressed second class citizens

it's very funny that you think this, in a lot of the countries in the region (notable exceptions being US allies like Saudi Arabia) women have the same rights and protections under the law, this has been the case for many many years in most of these countries, women's rights are lagging behind the west sure, but it's nowhere near as bad as you have been told, especially in more recent years

Agreed but sadly, when we look at history, it seems to happen quite often, no matter if we like it or not.

"Agreed but" no buts, this is not a justifiable action, the fact that it happened in the past doesn't justify current day actionsththe fact that the US and Britain committed genocide doesn't mean we should just give up on fucking stopping genocide, "no matter if we like it or not" we have reached an agreement that we don't like it, a global consensus that it is bad (other than the US and other western countries that support Israel, they love genocide), so we should stop people from committing genocide, if Russia starts to commit an actual genocide in Ukraine like Israel is doing in Gaza, then you'll no doubt agree that the world should sanction them, etc, in order to stop them, you just don't think Palestinians are people like Ukrainians are.

I fully agree with that statement. However this does not justify generalizing all Israeli citizens as child murderers.

During Hitlers rule of Nazi Germany, a very large number of Germans picked up arms and fought against their government, and were killed for it, mainly communists and leftists

But a lot Germans lived happily under and supported the actions of their government

Would you say those Germans that never lifted a finger to oppose the genocide and ethnic cleansing of jews were responsible for what happened? I'd say yes, they did not protest, did not resist, especially the ones that served in the army

Are you aware that the majority of Israeli citizens are reservists that will pick up arms to serve in the IDF if given the order? Are you aware that the IDF has a higher than 80% approval rating among Israelis? How are these people not complicit?

I fully agree with you that jews are just people like everyone else but we should also consider the regular antisemitic pogroms that happened throughout history, which are an obvious motivation for a community to get their own safe space in the world.

We should indeed consider those pogroms, every antisemite in Europe should be killed for their crimes, rather than what happened (governments with the help of NATO suppressing communists and leftists and promoting nationalistic (usually antisemitic) groups)

Also, all you've done with this argument is establish that "Jews should get an ethnostate" (I still disagree but I'll humor you for a second), you did not establish that a noble cause justifies ethnic cleansing and genocide, therefore the actions of Israel are no more acceptable than the actions of british settlers committing genocide against native Americans

Absolutely agree. Please keep in mind that I in fact never apologized any of the crimes of the IDF or the illegal settlers.

You did, continuously bringing up that zionists have a (in your view) noble cause is an attempt at the justification of ethnic cleansing and genocide

All I did was criticizing the antisemitic generalization of all citizens of Israel as casual child murderers.

They are complicit in the child murder.

Sadly it seems like most people's opinions are simply too polarized to get such nuances at this point.

You're a liberal.

uh, buddy, you're aware the US has that too right? like, by your own logic the chinese cannot control the UN any more than the US can, and I'm purely using what you've said, no other needed information about the history of what the UN says and sides most of the time with needed.

yes, obviously the UN and WHO are controlled by the evil see see pee

I condemn the racist politics of the right-extremist government of Israel and the social segregation and severe injustice it causes. What is your point?

Israel is an apartheid state, this isn't new, this isn't something that the current government did, this is the establishing principle of the state that has been held up since the start, calling an apartheid state "diverse" like you did in your first post is absolutely incorrect and is not close to the reality of the situation in any way shape or form, it's pure propaganda

There was this thing you all constantly choose to ignore, called the holocaust, that afaik not just a lot of antifascists see as a reason why Israel must exist, simply because otherwise the Jews will not survive capitalism.

having suffered in the past does not give a group of people free reign to commit those same acts against a separate unaffiliated population, having an ethnostate in the first place is not a good goal, but even if we said it was necessary, doing it through the ethnic cleansing and genocide of another group is not at all justifiable in any way.

treating things as if jews are simply different from regular people and could never survive as a minority in another country so they should not be judged by the same standard we apply to everyone is in itself an anti-semitic view to have, jews are regular people, committing genocide and ethnic cleansing is bad, whoever does it and however noble their goal is doesn't change that fact.