this post was submitted on 10 Nov 2023
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Article itself: Frontiers | Morphologic alterations of the fear circuitry: the role of sex hormones and oral contraceptives

Front. Endocrinol., 07 November 2023 https://doi.org/10.3389/fendo.2023.1228504

Background: Endogenous sex hormones and oral contraceptives (OCs) have been shown to influence key regions implicated in fear processing. While OC use has been found to impact brain morphology, methodological challenges remain to be addressed, such as avoiding selection bias between OC users and non-users, as well as examining potential lasting effects of OC intake.

Objective: We investigated the current and lasting effects of OC use, as well as the interplay between the current hormonal milieu and history of hormonal contraception use on structural correlates of the fear circuitry. We also examined the role of endogenous and exogenous sex hormones within this network.

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