See here's the thing I don't understand about this. And yes I've heard of this before. But both Adderall and Vyvanse say on their pharmacy forms that you can mix the medication in with orange juice to take it... So obviously the manufacturers aren't too worried about citric acid.
this post was submitted on 01 Jul 2023
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When/where does it say this? Does it still say this? It's entirely possible newer research has come out since they suggested the above.
My last script I filled had it with the paper work.
Is yours extended release?
Yes
That's an important note I failed to mention in my post. This seems to only impact instant release medications
man this is something else I gotta look out for? first I cut caffeine then I gotta remember to take protein bars with them and now this? Can't I just live and eat like a normal human?? ;-;
Huh, i thought only grapefruit affects the medication.
The only difference I feel is whenever the soda contains caffeine, which of course causes quite the ruckus in my brain depending on how much I accidentally drink.
When I took Vyvanse I couldn't eat grapefruit. It made me throw up and then I developed an aversion to it, and even now almost a decade since I stopped taking it I still really dislike grapefruit. I'm not sure if it's because of the citric acid content or what else, but oranges didn't ever bother me in that way.
Grapefruit has a unique effect on a dietary enzyme:
Many drugs are broken down (metabolized) with the help of a vital enzyme called CYP3A4 in the small intestine. Grapefruit juice can block the action of intestinal CYP3A4, so instead of being metabolized, more of the drug enters the blood and stays in the body longer. The result: too much drug in your body.
https://www.fda.gov/consumers/consumer-updates/grapefruit-juice-and-some-drugs-dont-mix
Read up about the specific medication that you're taking and there should be warnings or contra indicators for food intake along with that medication. All meds react differently and the companies making them will specify any requirements.
https://www.pharmacologyeducation.org/pharmacology/drug-absorption
It's more of a concern for instant release medications than it is for extended release medications, so things like vyvanse/concerta shouldn't be particularly effected
Yea, I've seen the same thing as well. Mine is instant release, twice a day. At least to start out. The extended release does sound kind of nice, though