this post was submitted on 07 Jul 2023
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This is super cool! And they were able to make another major chemical precursor too. I see the yield for ibuprofen is only 64% but I have to assume that’s there room to optimize that reaction scheme to generate higher yields!
I would love to see the full synthesis process as well as reaction conditions, but like everyone else who leaves academia I lost access to journals after finishing my grad program.
https://chemistry-europe.onlinelibrary.wiley.com/doi/epdf/10.1002/cssc.202300670
Thank you!!