this post was submitted on 06 Dec 2023
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All of the vaccines so far target the spike protein, so looking for spike antibodies won't tell you anything. If you test for nucleocapsid antibodies, however, and those show up, then you've definitely been infected. Even testing for N is not definitive, as very mild/asymptomatic cases may not develop an N response, and it does fade over time. I know there were studies to see if anti-RBD testing would work better, but I'm not sure what the results were.