Despite being a heavy cell phone user for more than 25 years, it only recently occurred to me that vertical navigation on most phones is inverted when compared to traditional computers. You swipe down to navigate upward, and up to navigate downward. I recently spent time using a MacBook, which apparently defaults to this "natural" scrolling (mobile-style), and I was completely thrown off by it.
I've been using natural scrolling on a couple of my own desktops ever since, mostly as a mental exercise, and I wondered...how many of you folks prefer this method?
Generally it's more about the interaction. If the user views it as interacting with the viewport, it tends to be inverted. If the user views the interaction as interacting with the scroll bar, it's "natural". Scroll wheel is the only odd one out. However it was introduced prior to mousepads supporting gestures. So it basically started as an extension of the scroll bar interaction, but as mousepads introduced the concept of interacting with the viewport, scroll wheels were given the option to respond either way based on user preference.