this post was submitted on 20 May 2025
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Privacy
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99.9% of your genome is exactly identical to every other human on Earth. <0.1% just means they aren't storing things that don't change between people, because why would they?
The 99.9% similarity refers to humans having nearly identical DNA sequences, but that doesn’t mean we express our genes the same way. Gene expression varies widely due to regulatory sequences, environmental factors, epigenetics, methylation, and more.
23andMe only analyzes a small, curated set of common SNPs, covering maybe 5 - 10 percent of the known functional and trait-associated genome. It doesn’t sequence most rare variants, the full exome, or structural elements.
Recent research is also starting to highlight the growing importance of the dark genome, revealing that non-coding regions we’ve dismissed as junk DNA play significant roles in regulation and disease.
That's all true, but also completely irrelevant to the point I was making. Gene expression isn't in that 99.9% of the DNA that is the same. All of the individually identifiable genetic information in the genome is in the other 0.1%. This is a privacy community. A complete understanding of how genetics works is neat and all, but it's not relevant to the conversation we're having. I didn't say that all humans 99.9% identical to each other. That's obviously not true. I said that there's no point in storing duplicate copies of identical genetic sequences, and that saying they store less than 0.1% of your genome only says they're not doing that.
For the record, 5-10% is way plenty to narrow things down to a very tiny number of people. Probably one in most cases, and it contains a lot of important medical information. That's not some trivial unimportant thing.