this post was submitted on 23 Jan 2025
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Again, I'm not trying to change your mind. I frankly am happy you have chosen a different path.
I literally linked you a RCT in the above post showing LDL being protective for all cause mortality
I do not consider this any more serious evidence than observational. Randomizing observational studies is an interesting way to determine where your next research should be, but not to draw conclusions.
evidence pyramid
Agreed. I don't think either of us are making progress with the other. And that's okay. We can both exist taking separate choices.
This is unfair, because I have provided that information above, I've read all of your links. I don't think you've read any of mine. To be quite frank, I think you've already decided what the right outcome is, you're going through the motions to overwhelm me, but not to engage in an actual intellectual discovery. We're not having a conversation, you're throwing papers at me. That's why we're not progressing
I did read your links, I think it is very interesting but doesn't really move the needle much when we have so much evidence to the contrary
Some Commentary on the linked RCT: https://nutritionsource.hsph.harvard.edu/2016/04/13/diet-heart-ramsden-mce-bmj-comments/. https://ebm.bmj.com/content/21/5/185.full
The study design, in mental health patients, of creating so many artificial foods with corn oil/ omega 6 and no omega 3 as well as the limited monitoring of cholesterol levels and limited length of the study also limits the interpretation of the results. The potential correlation of sudden cholesterol drop with mortality can also be confounded by sudden weight loss, which correlates with diseases like cancer.
Meta analysis of 60 RCT’s linking LDL-C lowering therapies with reduced CVD events:
https://www.atherosclerosis-journal.com/article/S0021-9150(24)01108-0/fulltext
How do you explain how statins reduce risk of CVD events or why those with familial hypercholesterolemia have such high rates of CVD?
It also still does nothing to address apo-b…