Kena: Bridge of Spirits is good. I still gotta finish it, but I've enjoyed it so far.
Gaming
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Kena was great. There was so much more they could have done with that world and Kena's backstory, but I think it's the #1 best looking game I've ever played.
Alien: Isolation!
This is a very obscure one, but there is a mod for Freespace 2 called Blue Planet: War in Heaven which has an amazingly well written story and female lead.
How about Final Fantasy XIII? The first game has a full sized party, but Lightning is clearly the main character and the focus. Second game costars Lightning's younger sister and a new male character. Third game is just Lighting.
By NOLF you mean No One Lives Forever? If so a quick search gave me this "revival" site, seeing the Windows targets i bet that runs on Wine
Good is an incredibly subjective term. May be you can try Control. Or, if you're into rythm games and metal, I'd recommend Metal: Hellsinger.
I just started playing Asscreed Odyssey last week, having fun so far. A bit of a departure for the series, more of a Witcher-style open world action-adventure game in ancient Greece. You can select between player characters Alexios (male) and Kassandra (female), I picked Kassandra, I like her, she seems decently written and the voice acting is great.
Elden Ring is incredible, although it's silent protagonist (aside from grunts etc), and might be too difficult. I know many women who love it though.
CrossCode is an excellent neo-retro overhead 2D action RPG. Great combat system, puzzles, and story.
Valheim isn't very story heavy but it's an incredible exploration/survival/crafting game, one of my all time favourites.
Steve Jackson's Sorcery! Parts 1 & 2 (and sequels Part 3 and Part 4): Masterfully crafted interactive "choose your own adventure" videogame, pretty much a video-book with an immersive story and wonderful illustrations. Highly recommended, I've been enjoying Jerma985's streams of it. You're constantly making choices that will completely change the outcome of the game, there is a rewind button if you need it.
Control has already been mentioned by others, I also recommend it. Great writing, graphics, lots of humour in the environment. Especially if you're a fan of SCP. Honestly the combat got a little monotonous towards the end but it didn't overstay its welcome. The documents you find around the world are hilarious and well worth a read.
Here's one a ton of people slept on, Disciples Liberation. The protagonist is a chick, you can be pious, kind, hateful, evil and/or fuck your way through the entire world if you want. You can be bi, straight, not get involved in romance at all, doesn't matter. But no matter how you play, you are an absolute badass that can barely beat two soldiers at the start and can nuke literal gods by the end.
Alba is a very cute and relaxing game, but it's good! And the eponymous main character is a little girl.
Play Sea of Thieves as a female.
The Longest Journey, Dreamfall, Dreamfall Chapters
This is what I was coming here to recommend. April is a great character, and the series is really good. The first is very much old-school point & click, with the sometimes highly obscure puzzles that entails, but the story is excellent.
Metroid: Fusion is pretty fun!
If you're into farming and dungeon delving, Rune Factory 4 has a female protagonist option.
Rune factory 4 actually came to PC as of 2021 so you don't have to own a 3ds to play it anymore. I'm currently playing RF5, and I'm enjoying it.
Celeste!
Played Sakuna: Of Rice and Ruin recently
fantastic game. The platforming is fun with surprising depth. The Rice mechanics have way more depth than I can stand, but it's still forgiving enough that you never feel severely punished for messing up.
i love this game, glad it was really successful too, I wanna see more from those devs. felt like a 2D Okami spin-off
I really wanted to like Sakuna, but I just... couldn't. The platforming combat is really stiff, and the game is pretty bad at explaining mechanics. Oddly enough, I found the rice farming to be the most interesting part! Unfortunately, rice farming is essentially just there to provide buffs for the platforming, so I stopped playing after about 10 hours.
It's stiff at first, but you get a lot of tools to improve it. One of the moves is basically a dash similar to a megaman x game, that can be used up to 2 times and go in all cardinal directions.
That on top of the wall grab makes her feel a lot smoother later on in the game.
Also this is not even including for combat you get Iatsu and the dash I talked about earlier, which let you move all over the combat area. That on top of countering attacks and the skill specifically for countering attacks. Iatsu needs to be leveled up before you really feel how strong it is though.
the rice farming is indeed meant to make the platforming easier, so it might not be as great if you didn't enjoy that part of it.
I do agree though the game is horrible at explaining this stuff though, which can make some parts more frustrating than they need to be.
Passing By (I think Curly is technically gender-neutral but I always saw her as a girl).
I think the download files got taken down though unfortunately
Edit: Apparantly they've been canonically made non-binary