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1, it's aspartame
2, Mice aren't humans, and routinely, things that happen in mice do not happen in humans. It is not at all indicative of anything and can really only be used as a hint better than nothing for looking into similar effects in humans.
You don't need to change your diet, and you certainly don't need to replace it with sugar.
Removing all forms of added sugar would probably make everyone feel better. Even minimizing natural sugar intake.
Sugar is terrible, there’s no doubt about it. Artificial or otherwise.
There’s nothing inherently bad about sugar. It’s just energy. If you intake more energy than you burn it’s getting stored for future use (you get fat). The same goes for almost anything “unhealthy”. Manage your energy intake and almost nothing is unhealthy.