this post was submitted on 06 Sep 2024
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Science

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[–] [email protected] 25 points 1 week ago (7 children)

This has been posted to a bunch of different communities, and I’m gonna be a stick in the mud each time.

I’m a process chemist. I do this for a living. I’ve made kilo-scale batches of pharmaceuticals at work that have gone through the regulatory process and made it into people. I went to school for ten years to do this.

This is a colossally dangerous thing.

Every time you run a chemical synthesis, you generate impurities. Slightly different temperatures, concentrations, reagent quality, and a million other things will vary the identities and concentrations of those impurities in your product.

The nature of biochemistry is that most compounds, even at very small concentrations, can have effects. Usually bad ones. So drugs have tight specs on how much of each potential impurity can be present. Usually it’s in the 0.1% range, but sometimes a lot lower.

Detection of impurities at that level cannot be done with ‘hacker’ gear in your garage. So if you do this, you’re going to be taking unknown quantities of unknown impurities.

There are trade-offs. If you’re definitely gonna die without the medicine, then the worst that can happen is you die faster, or more painfully. If it’s medicine to maintain quality of life, then you might die fast and painfully.

I’m not saying the current system is good at all. Medicine is too expensive. It shouldn’t be limited by right wing nutjobs. Those things are true. Those things require a solution.

This is not a good solution.

[–] [email protected] 8 points 1 week ago (1 children)

I appreciate your warning, and would like to echo it, from a safety perspective.

I would also like to point out that we should be approaching this, as every risk, from a harm reduction standpoint. A drug with impurities that could save your life or prevent serious harm is better than no drug and death. People need to be empowered to make the best decisions they can, given the available resources and education.

[–] [email protected] 3 points 1 week ago

make the best decisions they can

I would recommend an HPLC and a competent analytical chemist to gather data and decide whether or not a batch is safe to consume.

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