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Had this conversation with someone who chose to no longer be at my table after meeting a blind NPC
(files.catbox.moe)
Another player who was at the table during the incident sent me this meme after the problem player in question (they had a history) left the group chat.
Felt like sharing it here because I'm sure more people should keep this kind of thing in mind.
Depends on the nature of the disability I would say.
A neurological disorder of some sort or some other difference would likely not be curable but some sort of magical item could assist, rather than completely 'fix' the issue. It would be kind of fun to see how a high charisma character with autism handles things though.
Mobility issues could be routed around with enchantments and such or the use of some kind of frame or wheelchair even. Something fancy or something crudely constructed.